{
  "timestamp": "2026-04-21T00:54:32.358004",
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          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/0 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
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          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
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            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
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          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
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            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/6 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
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          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/6 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
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          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/10 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
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          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/11 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
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          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/16 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
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          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/17 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
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          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/23 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
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            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/25 violates domain constraint: predicate 'biolink:precedes' expects domain 'occurrent' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
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          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/25 violates range constraint: predicate 'biolink:precedes' expects range 'occurrent' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
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          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/29 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
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          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/30 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
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          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/32 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
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          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/33 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
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          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/39 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
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          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/41 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
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          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/42 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
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          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/43 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
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          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/45 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
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          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/48 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
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          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/49 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
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          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/50 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
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          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/51 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
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            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/61 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
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          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/62 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
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          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/63 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
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          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/64 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
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          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/67 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
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          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/68 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
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          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/74 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
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          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/77 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/78 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/83 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/97 violates range constraint: predicate 'biolink:acts_upstream_of_negative_effect' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/98 violates domain constraint: predicate 'biolink:precedes' expects domain 'occurrent' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/98 violates range constraint: predicate 'biolink:precedes' expects range 'occurrent' but object has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/99 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/104 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/107 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/109 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/110 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/124 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/128 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/136 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/140 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/144 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/146 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/148 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/154 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/156 violates domain constraint: predicate 'biolink:precedes' expects domain 'occurrent' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/156 violates range constraint: predicate 'biolink:precedes' expects range 'occurrent' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/162 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/163 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/165 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/168 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/170 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/171 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/174 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/180 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/181 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/185 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/186 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/188 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/189 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/193 violates domain constraint: predicate 'biolink:acts_upstream_of' expects domain 'gene or gene product' but subject has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/193 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/194 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/196 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/198 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/199 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/200 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/203 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/204 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/206 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/208 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/211 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/215 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/216 violates range constraint: predicate 'biolink:acts_upstream_of_or_within' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/218 violates domain constraint: predicate 'biolink:precedes' expects domain 'occurrent' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/218 violates range constraint: predicate 'biolink:precedes' expects range 'occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/220 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/221 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/224 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/229 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/233 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/241 violates domain constraint: predicate 'biolink:precedes' expects domain 'occurrent' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/241 violates range constraint: predicate 'biolink:precedes' expects range 'occurrent' but object has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/242 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/243 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/245 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/249 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/250 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/251 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/255 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/257 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/259 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/261 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/262 violates domain constraint: predicate 'biolink:precedes' expects domain 'occurrent' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/262 violates range constraint: predicate 'biolink:precedes' expects range 'occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/263 violates domain constraint: predicate 'biolink:acts_upstream_of' expects domain 'gene or gene product' but subject has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/263 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/269 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/270 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/271 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/274 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/288 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/295 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/296 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/298 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/299 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/300 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/301 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/306 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/308 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/309 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/310 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/319 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/321 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/323 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/331 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/335 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/336 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/339 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/344 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/345 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/348 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/350 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/354 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/362 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/363 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/364 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/369 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/372 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/373 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/375 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/379 violates range constraint: predicate 'biolink:acts_upstream_of_negative_effect' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/380 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/381 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/382 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/384 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/385 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/396 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/397 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/399 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/414 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/417 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/418 violates domain constraint: predicate 'biolink:precedes' expects domain 'occurrent' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/418 violates range constraint: predicate 'biolink:precedes' expects range 'occurrent' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/421 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/422 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/424 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/430 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/437 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/444 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/448 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/452 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/456 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/464 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/467 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/468 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/469 violates domain constraint: predicate 'biolink:precedes' expects domain 'occurrent' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/469 violates range constraint: predicate 'biolink:precedes' expects range 'occurrent' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/476 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/480 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/481 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/482 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/492 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/493 violates domain constraint: predicate 'biolink:precedes' expects domain 'occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/493 violates range constraint: predicate 'biolink:precedes' expects range 'occurrent' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/500 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/504 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/506 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/507 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/510 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/515 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/516 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/519 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/521 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/524 violates domain constraint: predicate 'biolink:acts_upstream_of' expects domain 'gene or gene product' but subject has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/524 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/528 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/530 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/533 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/535 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/536 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/537 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/538 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/540 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/540 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/541 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/545 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/547 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/548 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/551 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/551 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/553 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/555 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/558 violates range constraint: predicate 'biolink:acts_upstream_of_negative_effect' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/560 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/562 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/563 violates domain constraint: predicate 'biolink:acts_upstream_of' expects domain 'gene or gene product' but subject has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/563 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/565 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/568 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/573 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/574 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/585 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/589 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/594 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/595 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/597 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/599 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/603 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/607 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/608 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/610 violates domain constraint: predicate 'biolink:enables' expects domain 'physical entity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/610 violates range constraint: predicate 'biolink:enables' expects range 'biological process or activity' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/611 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/613 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/615 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/625 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/626 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/629 violates range constraint: predicate 'biolink:acts_upstream_of_or_within' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/630 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/633 violates domain constraint: predicate 'biolink:precedes' expects domain 'occurrent' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/633 violates range constraint: predicate 'biolink:precedes' expects range 'occurrent' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/637 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/638 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/644 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/646 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/648 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/649 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/650 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/652 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/656 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/658 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/666 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/672 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/674 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/680 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/684 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/687 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/689 violates range constraint: predicate 'biolink:acts_upstream_of_negative_effect' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/695 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/700 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/704 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/709 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/711 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/714 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/718 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/720 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/724 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/725 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/729 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/737 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/742 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/743 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/748 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/749 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/757 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/762 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/764 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/770 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/775 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/776 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/777 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/785 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/787 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/788 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/789 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/791 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/795 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/797 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/802 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/805 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/809 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/810 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/811 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/812 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/824 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/825 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/826 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/827 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/828 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/831 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/833 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/834 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/851 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/855 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/857 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/860 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/862 violates domain constraint: predicate 'biolink:precedes' expects domain 'occurrent' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/862 violates range constraint: predicate 'biolink:precedes' expects range 'occurrent' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/863 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/864 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/865 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/867 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/881 violates range constraint: predicate 'biolink:acts_upstream_of_negative_effect' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/904 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/908 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/911 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/914 violates range constraint: predicate 'biolink:acts_upstream_of_negative_effect' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/915 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/916 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/917 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/918 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/923 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/923 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/926 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/927 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/929 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/930 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/931 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/938 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/940 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/945 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/947 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/948 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/952 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/953 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/959 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/961 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/962 violates range constraint: predicate 'biolink:acts_upstream_of_or_within' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/963 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/967 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/968 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/971 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/972 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/973 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/974 violates range constraint: predicate 'biolink:acts_upstream_of_negative_effect' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/975 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/976 violates domain constraint: predicate 'biolink:precedes' expects domain 'occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/976 violates range constraint: predicate 'biolink:precedes' expects range 'occurrent' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/977 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/978 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/979 violates domain constraint: predicate 'biolink:precedes' expects domain 'occurrent' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/979 violates range constraint: predicate 'biolink:precedes' expects range 'occurrent' but object has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/984 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/988 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/989 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/992 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/998 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/999 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1005 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1009 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1010 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1012 violates domain constraint: predicate 'biolink:precedes' expects domain 'occurrent' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1012 violates range constraint: predicate 'biolink:precedes' expects range 'occurrent' but object has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1013 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1016 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1019 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1022 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1026 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1027 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1028 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1030 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1032 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1034 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1035 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1042 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1043 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1044 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1046 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1058 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1061 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1062 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1064 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1066 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1068 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1072 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1075 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1077 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1078 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1081 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1084 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1087 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1089 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1091 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1097 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1102 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1105 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1107 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1110 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1116 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1122 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1123 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1125 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1130 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1134 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1135 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1137 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1147 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1152 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1154 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1158 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1159 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1162 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1164 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1168 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1169 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1179 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1183 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1188 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1189 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1190 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1193 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1200 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1210 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1212 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1224 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1225 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1226 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1233 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1234 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1236 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1239 violates domain constraint: predicate 'biolink:precedes' expects domain 'occurrent' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1239 violates range constraint: predicate 'biolink:precedes' expects range 'occurrent' but object has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1240 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1244 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1245 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1250 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1253 violates domain constraint: predicate 'biolink:precedes' expects domain 'occurrent' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1253 violates range constraint: predicate 'biolink:precedes' expects range 'occurrent' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1254 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1255 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1260 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1263 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1266 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1268 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1273 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1283 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1285 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1286 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1287 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1288 violates domain constraint: predicate 'biolink:precedes' expects domain 'occurrent' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1288 violates range constraint: predicate 'biolink:precedes' expects range 'occurrent' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1292 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1293 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1296 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1300 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1301 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1303 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1305 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1309 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1310 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1318 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1319 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1321 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1324 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1331 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1335 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1337 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1339 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1341 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1343 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1344 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1345 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1348 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1349 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1350 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1353 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1354 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1357 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1361 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1362 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1363 violates range constraint: predicate 'biolink:acts_upstream_of_negative_effect' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1365 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1368 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1376 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1377 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1378 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1381 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1387 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1391 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1395 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1397 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1399 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1400 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1401 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1403 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1404 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1410 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1411 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1415 violates domain constraint: predicate 'biolink:precedes' expects domain 'occurrent' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1415 violates range constraint: predicate 'biolink:precedes' expects range 'occurrent' but object has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1417 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1418 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1419 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1424 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1428 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1435 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1439 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1440 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1443 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1445 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1448 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1452 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1453 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1454 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1456 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1458 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1460 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1470 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1472 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1473 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1474 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1479 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1483 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1499 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1506 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1513 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1515 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1516 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1518 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1520 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1525 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1527 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1531 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1532 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1538 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1540 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1545 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1546 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1547 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1549 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1553 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:ChemicalEntity', 'biolink:PhysicalEssence', 'biolink:ChemicalOrDrugOrTreatment', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1558 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1560 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1563 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1567 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1568 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1569 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1572 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1574 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1575 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1577 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1581 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1585 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1588 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1590 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1592 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1595 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1596 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1607 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1609 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1615 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1620 violates range constraint: predicate 'biolink:acts_upstream_of_negative_effect' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1625 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1630 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1631 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1635 violates domain constraint: predicate 'biolink:precedes' expects domain 'occurrent' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1635 violates range constraint: predicate 'biolink:precedes' expects range 'occurrent' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1640 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1641 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1643 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1644 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1647 violates domain constraint: predicate 'biolink:precedes' expects domain 'occurrent' but subject has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1647 violates range constraint: predicate 'biolink:precedes' expects range 'occurrent' but object has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1653 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1654 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1656 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1660 violates domain constraint: predicate 'biolink:acts_upstream_of' expects domain 'gene or gene product' but subject has categories ['biolink:ChemicalEntity', 'biolink:PhysicalEssence', 'biolink:ChemicalOrDrugOrTreatment', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1660 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1666 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1675 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1679 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1687 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1688 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1693 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1694 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1701 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1702 violates range constraint: predicate 'biolink:acts_upstream_of_negative_effect' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1704 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1706 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1708 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1708 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1709 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1710 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1719 violates range constraint: predicate 'biolink:acts_upstream_of_negative_effect' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1725 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1726 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1728 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1729 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1738 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1739 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1742 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1744 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1746 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1748 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1748 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1749 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1751 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1758 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1759 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1765 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1768 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1770 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1773 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1774 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1781 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1783 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1784 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1787 violates range constraint: predicate 'biolink:acts_upstream_of_negative_effect' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1800 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1801 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1803 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1804 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1805 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1811 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1814 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1820 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1823 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1833 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1834 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1836 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1838 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1840 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1842 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1843 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1844 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1845 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1846 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1849 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1850 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1853 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1859 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1862 violates domain constraint: predicate 'biolink:precedes' expects domain 'occurrent' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1862 violates range constraint: predicate 'biolink:precedes' expects range 'occurrent' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1863 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1865 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1867 violates range constraint: predicate 'biolink:acts_upstream_of_negative_effect' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1868 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1872 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1873 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1875 violates domain constraint: predicate 'biolink:acts_upstream_of' expects domain 'gene or gene product' but subject has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1875 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1879 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1881 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1882 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1884 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1885 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1886 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1887 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1888 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1889 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1892 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1893 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1894 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1898 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1899 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1901 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1902 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1904 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1905 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1906 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1908 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1909 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1910 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1916 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1917 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1923 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1925 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1927 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1932 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1935 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1941 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1944 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1948 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1950 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1952 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1957 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1960 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1961 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1963 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1964 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1965 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1966 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1975 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1976 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1977 violates range constraint: predicate 'biolink:acts_upstream_of_negative_effect' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1979 violates domain constraint: predicate 'biolink:acts_upstream_of' expects domain 'gene or gene product' but subject has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1979 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1984 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1986 violates range constraint: predicate 'biolink:acts_upstream_of_negative_effect' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1987 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1991 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/1998 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2006 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2010 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2022 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2045 violates domain constraint: predicate 'biolink:acts_upstream_of' expects domain 'gene or gene product' but subject has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2045 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2048 violates domain constraint: predicate 'biolink:precedes' expects domain 'occurrent' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2048 violates range constraint: predicate 'biolink:precedes' expects range 'occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2049 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2050 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2064 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2067 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2068 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2075 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2077 violates domain constraint: predicate 'biolink:acts_upstream_of' expects domain 'gene or gene product' but subject has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2077 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2081 violates domain constraint: predicate 'biolink:precedes' expects domain 'occurrent' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2081 violates range constraint: predicate 'biolink:precedes' expects range 'occurrent' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2082 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2086 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2091 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2092 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2100 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2101 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2103 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2107 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2111 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2116 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2117 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2119 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2122 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2125 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2131 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2133 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2135 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2139 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2143 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2149 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2152 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2156 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2159 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2163 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2166 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2173 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2176 violates domain constraint: predicate 'biolink:acts_upstream_of' expects domain 'gene or gene product' but subject has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2176 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2179 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2181 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2187 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2188 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2190 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2191 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2194 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2195 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2196 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2200 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2204 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2208 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2209 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2212 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2214 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2217 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2219 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2220 violates domain constraint: predicate 'biolink:precedes' expects domain 'occurrent' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2220 violates range constraint: predicate 'biolink:precedes' expects range 'occurrent' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2222 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2232 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2234 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2235 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2238 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2245 violates domain constraint: predicate 'biolink:precedes' expects domain 'occurrent' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2245 violates range constraint: predicate 'biolink:precedes' expects range 'occurrent' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2246 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2251 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2253 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2258 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2259 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2265 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2267 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2274 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2278 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2281 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2283 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2287 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2290 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2293 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2296 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2301 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2309 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2311 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2312 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2314 violates range constraint: predicate 'biolink:acts_upstream_of_negative_effect' expects range 'biological process' but object has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2318 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2327 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2331 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2334 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2335 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2340 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2342 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2346 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2347 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2347 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2349 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2351 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2352 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2353 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2359 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2361 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2362 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2364 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2376 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2379 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2381 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2383 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2384 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2385 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2389 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2390 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2398 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2403 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2408 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2409 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2411 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2414 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2421 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2423 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2425 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2428 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2429 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2434 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2438 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2439 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2439 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2441 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2443 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2444 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2445 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2448 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2453 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2455 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2462 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2464 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2467 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2477 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2479 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2480 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2485 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2487 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2488 violates domain constraint: predicate 'biolink:precedes' expects domain 'occurrent' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2488 violates range constraint: predicate 'biolink:precedes' expects range 'occurrent' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2491 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2493 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2495 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2496 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2497 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2498 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2501 violates range constraint: predicate 'biolink:acts_upstream_of_negative_effect' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2502 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2503 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2510 violates range constraint: predicate 'biolink:acts_upstream_of_negative_effect' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2511 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2513 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2514 violates domain constraint: predicate 'biolink:precedes' expects domain 'occurrent' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2514 violates range constraint: predicate 'biolink:precedes' expects range 'occurrent' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2515 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2518 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2521 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:ChemicalEntity', 'biolink:PhysicalEssence', 'biolink:ChemicalOrDrugOrTreatment', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2522 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2523 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2524 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2527 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2528 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2529 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2530 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2536 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2540 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2542 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2544 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2545 violates range constraint: predicate 'biolink:acts_upstream_of_negative_effect' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2549 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2550 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2552 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2553 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2555 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2563 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2574 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2576 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2580 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2581 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2582 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2586 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2596 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2597 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2599 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2602 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2604 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2614 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2622 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2624 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2625 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2629 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2630 violates range constraint: predicate 'biolink:acts_upstream_of_negative_effect' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2633 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2634 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2636 violates domain constraint: predicate 'biolink:acts_upstream_of' expects domain 'gene or gene product' but subject has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2636 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2637 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2640 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2641 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2644 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2646 violates range constraint: predicate 'biolink:acts_upstream_of_negative_effect' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2659 violates domain constraint: predicate 'biolink:acts_upstream_of' expects domain 'gene or gene product' but subject has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2659 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2669 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2673 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2674 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2675 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2680 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2684 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2686 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2688 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2693 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2696 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2697 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2698 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2703 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2704 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2707 violates range constraint: predicate 'biolink:acts_upstream_of_negative_effect' expects range 'biological process' but object has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2708 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2713 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2716 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2721 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2725 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2728 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2733 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2737 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2740 violates domain constraint: predicate 'biolink:precedes' expects domain 'occurrent' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2740 violates range constraint: predicate 'biolink:precedes' expects range 'occurrent' but object has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2743 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2746 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2750 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2752 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2754 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2759 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2760 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2762 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2763 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2763 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2771 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2780 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2787 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2789 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2795 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2797 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2800 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2803 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2807 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2813 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2816 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2818 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2819 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2824 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2831 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2834 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2835 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2839 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2842 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2845 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2847 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2849 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2853 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2854 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2855 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2856 violates domain constraint: predicate 'biolink:precedes' expects domain 'occurrent' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2856 violates range constraint: predicate 'biolink:precedes' expects range 'occurrent' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2857 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2861 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2862 violates domain constraint: predicate 'biolink:precedes' expects domain 'occurrent' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2862 violates range constraint: predicate 'biolink:precedes' expects range 'occurrent' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2866 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2868 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2870 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2871 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2875 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2877 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2881 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2886 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2890 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2894 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2895 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2896 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2898 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2903 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2906 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2910 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2912 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2914 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2915 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2916 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2927 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2935 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2938 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2940 violates range constraint: predicate 'biolink:acts_upstream_of_negative_effect' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2942 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2947 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2949 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2955 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2956 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2957 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2960 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2961 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2964 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2967 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2972 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2973 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2974 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2976 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2978 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2981 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2983 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2984 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2987 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2989 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2991 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2991 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2992 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2995 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2997 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/2998 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3004 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3006 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3007 violates domain constraint: predicate 'biolink:precedes' expects domain 'occurrent' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3007 violates range constraint: predicate 'biolink:precedes' expects range 'occurrent' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3009 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3011 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3013 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3016 violates domain constraint: predicate 'biolink:precedes' expects domain 'occurrent' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3016 violates range constraint: predicate 'biolink:precedes' expects range 'occurrent' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3018 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3019 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3023 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3024 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3029 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3030 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3031 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3037 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3040 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3040 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3041 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3049 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3050 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3052 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3052 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3055 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3056 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3058 violates range constraint: predicate 'biolink:acts_upstream_of_negative_effect' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3065 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3067 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3069 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3070 violates domain constraint: predicate 'biolink:precedes' expects domain 'occurrent' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3070 violates range constraint: predicate 'biolink:precedes' expects range 'occurrent' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3074 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3078 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3081 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3087 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3088 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3092 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3093 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3094 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3095 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3096 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3097 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3110 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3111 violates range constraint: predicate 'biolink:acts_upstream_of_negative_effect' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3113 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3125 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3128 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3132 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3135 violates domain constraint: predicate 'biolink:precedes' expects domain 'occurrent' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3135 violates range constraint: predicate 'biolink:precedes' expects range 'occurrent' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3141 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3146 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3149 violates range constraint: predicate 'biolink:acts_upstream_of_negative_effect' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3150 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3152 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3154 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3161 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3163 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3166 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3170 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3171 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3172 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3173 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3179 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3184 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3186 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3190 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3192 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3193 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3194 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3196 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3197 violates range constraint: predicate 'biolink:acts_upstream_of_negative_effect' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3201 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3202 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3203 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3207 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3211 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3227 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3228 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3231 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3234 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3238 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3241 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3243 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3245 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3249 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3253 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3256 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3258 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3259 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3263 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3268 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3269 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3270 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3271 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3272 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3277 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3283 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3289 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3292 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3296 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3301 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3302 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3304 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3305 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3305 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3306 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3307 violates domain constraint: predicate 'biolink:precedes' expects domain 'occurrent' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3307 violates range constraint: predicate 'biolink:precedes' expects range 'occurrent' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3309 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3312 violates domain constraint: predicate 'biolink:acts_upstream_of' expects domain 'gene or gene product' but subject has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3312 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3313 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3315 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3316 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3336 violates domain constraint: predicate 'biolink:acts_upstream_of_negative_effect' expects domain 'gene or gene product' but subject has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3336 violates range constraint: predicate 'biolink:acts_upstream_of_negative_effect' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3339 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3344 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3346 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3347 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3349 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3354 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3356 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3371 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3372 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3373 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3374 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3384 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3387 violates range constraint: predicate 'biolink:acts_upstream_of_or_within' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3392 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3395 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3398 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3399 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3406 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3408 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3409 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3412 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3414 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3420 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3430 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3432 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3434 violates range constraint: predicate 'biolink:acts_upstream_of_negative_effect' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3437 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3439 violates domain constraint: predicate 'biolink:precedes' expects domain 'occurrent' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3439 violates range constraint: predicate 'biolink:precedes' expects range 'occurrent' but object has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3440 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3442 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3452 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3453 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3454 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3455 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3456 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3458 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3459 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3461 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3466 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3467 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3473 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3476 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3477 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3481 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3485 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3489 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3492 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3493 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3494 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3503 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3504 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3506 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3509 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3510 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3516 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3521 violates domain constraint: predicate 'biolink:acts_upstream_of' expects domain 'gene or gene product' but subject has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3521 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3522 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3525 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3526 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3528 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3531 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3534 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3536 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3536 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3537 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3539 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3543 violates domain constraint: predicate 'biolink:precedes' expects domain 'occurrent' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3543 violates range constraint: predicate 'biolink:precedes' expects range 'occurrent' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3545 violates range constraint: predicate 'biolink:acts_upstream_of_negative_effect' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3550 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3554 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3556 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3572 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3575 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3592 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3596 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3598 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3604 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3605 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3607 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3610 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3611 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3621 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3622 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3623 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3628 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3631 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3632 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3633 violates domain constraint: predicate 'biolink:precedes' expects domain 'occurrent' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3633 violates range constraint: predicate 'biolink:precedes' expects range 'occurrent' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3636 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3640 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3641 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3643 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3646 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3647 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3657 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3658 violates range constraint: predicate 'biolink:acts_upstream_of_negative_effect' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3660 violates domain constraint: predicate 'biolink:precedes' expects domain 'occurrent' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3660 violates range constraint: predicate 'biolink:precedes' expects range 'occurrent' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3665 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3668 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3669 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3671 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3674 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3677 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3683 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3691 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3693 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3694 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3697 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3699 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3706 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3709 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3710 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3712 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3714 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3715 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3716 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3717 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3719 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3721 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3724 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3725 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3727 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3729 violates range constraint: predicate 'biolink:acts_upstream_of_or_within' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3730 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3731 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3733 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3733 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3734 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3735 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3738 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3741 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3744 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3745 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3748 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3751 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3754 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3760 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3762 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3763 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3764 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3765 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3766 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3767 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3771 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3772 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3773 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3774 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3780 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3784 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3787 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3791 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3794 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3795 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3799 violates range constraint: predicate 'biolink:acts_upstream_of_negative_effect' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3800 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3805 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3808 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3812 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3814 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3817 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3819 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3821 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3826 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3827 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3828 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3829 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3832 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3836 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3839 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3843 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3846 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3847 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3850 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3854 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3862 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3865 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3867 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3874 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3878 violates domain constraint: predicate 'biolink:precedes' expects domain 'occurrent' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3878 violates range constraint: predicate 'biolink:precedes' expects range 'occurrent' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3880 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3881 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3886 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3889 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3889 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3892 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3894 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3895 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3896 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3908 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3912 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3922 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3923 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3930 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3939 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3945 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3948 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3950 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3951 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3959 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3960 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3963 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3964 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3965 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3967 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3968 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3969 violates domain constraint: predicate 'biolink:precedes' expects domain 'occurrent' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3969 violates range constraint: predicate 'biolink:precedes' expects range 'occurrent' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3973 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3982 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3983 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3987 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3989 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3991 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3992 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3993 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/3998 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4002 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4005 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4006 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4016 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4017 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4018 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4021 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4022 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4024 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4025 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4028 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4031 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4032 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4034 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4035 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4036 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4039 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4042 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4044 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4046 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4053 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4060 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4065 violates domain constraint: predicate 'biolink:precedes' expects domain 'occurrent' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4065 violates range constraint: predicate 'biolink:precedes' expects range 'occurrent' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4067 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4068 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4069 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4076 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4078 violates range constraint: predicate 'biolink:acts_upstream_of_negative_effect' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4085 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4086 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4090 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4094 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4096 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4100 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4102 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4105 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4110 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4112 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4113 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4114 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4117 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4122 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4124 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4126 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4127 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4129 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4131 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4133 violates range constraint: predicate 'biolink:acts_upstream_of_negative_effect' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4137 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4138 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4139 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4140 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4141 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4142 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4146 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4148 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4149 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4150 violates domain constraint: predicate 'biolink:precedes' expects domain 'occurrent' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4150 violates range constraint: predicate 'biolink:precedes' expects range 'occurrent' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4152 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4159 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4160 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4165 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4177 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4180 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4183 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4185 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4190 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4194 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4199 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4201 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4203 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4206 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4207 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4213 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4221 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4222 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4228 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4229 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4231 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4236 violates domain constraint: predicate 'biolink:precedes' expects domain 'occurrent' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4236 violates range constraint: predicate 'biolink:precedes' expects range 'occurrent' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4237 violates domain constraint: predicate 'biolink:precedes' expects domain 'occurrent' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4237 violates range constraint: predicate 'biolink:precedes' expects range 'occurrent' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4246 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4247 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4250 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4251 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4253 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4255 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4256 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4263 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4270 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4275 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4278 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4279 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4284 violates domain constraint: predicate 'biolink:acts_upstream_of' expects domain 'gene or gene product' but subject has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4284 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4296 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4299 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4301 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4302 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4306 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4308 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4309 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4310 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4318 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4320 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4327 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4328 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4334 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4338 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4340 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4342 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4343 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4348 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4353 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4354 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4358 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4362 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4366 violates domain constraint: predicate 'biolink:precedes' expects domain 'occurrent' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4366 violates range constraint: predicate 'biolink:precedes' expects range 'occurrent' but object has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4371 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4375 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4383 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4385 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4386 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4390 violates range constraint: predicate 'biolink:acts_upstream_of_or_within_negative_effect' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4391 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4392 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4395 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4397 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4398 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4400 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4407 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4407 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4410 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4412 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4413 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4415 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4418 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4420 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4421 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4426 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4429 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4436 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4437 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4438 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4439 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4443 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4447 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4450 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4451 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4457 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4458 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4461 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4463 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4464 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4467 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4468 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4472 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4474 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4481 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4485 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4489 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4490 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4492 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4494 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4495 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4501 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4504 violates domain constraint: predicate 'biolink:acts_upstream_of' expects domain 'gene or gene product' but subject has categories ['biolink:CellularComponent', 'biolink:AnatomicalEntity', 'biolink:PhysicalEssence', 'biolink:OrganismalEntity', 'biolink:SubjectOfInvestigation', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4504 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4514 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4516 violates domain constraint: predicate 'biolink:precedes' expects domain 'occurrent' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4516 violates range constraint: predicate 'biolink:precedes' expects range 'occurrent' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4517 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4519 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4526 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4527 violates range constraint: predicate 'biolink:acts_upstream_of_or_within' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4528 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4536 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4537 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4538 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4539 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4544 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4545 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4547 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4550 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4552 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4553 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4554 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4558 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4560 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4561 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4562 violates range constraint: predicate 'biolink:acts_upstream_of' expects range 'biological process' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4563 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4565 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4571 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4572 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4572 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4576 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4577 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4577 violates range constraint: predicate 'biolink:regulates' expects range 'physical essence or occurrent' but object has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4580 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4582 violates domain constraint: predicate 'biolink:regulates' expects domain 'physical essence or occurrent' but subject has categories ['biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:ChemicalEntityOrProteinOrPolypeptide', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:GeneOrGeneProduct', 'biolink:MacromolecularMachineMixin']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4585 violates domain constraint: predicate 'biolink:precedes' expects domain 'occurrent' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4585 violates range constraint: predicate 'biolink:precedes' expects range 'occurrent' but object has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          },
          {
            "type": "biolink-model validation",
            "severity": "WARN",
            "message": "Edge at /edges/4586 violates domain constraint: predicate 'biolink:has_input' expects domain 'biological process or activity' but subject has categories ['biolink:Gene', 'biolink:GeneOrGeneProduct', 'biolink:GenomicEntity', 'biolink:ChemicalEntityOrGeneOrGeneProduct', 'biolink:PhysicalEssence', 'biolink:OntologyClass', 'biolink:BiologicalEntity', 'biolink:ThingWithTaxon', 'biolink:NamedThing', 'biolink:PhysicalEssenceOrOccurrent', 'biolink:MacromolecularMachineMixin', 'biolink:Protein', 'biolink:GeneProductMixin', 'biolink:Polypeptide', 'biolink:ChemicalEntityOrProteinOrPolypeptide']",
            "instance_path": "unknown"
          }
        ],
        "missing_nodes": [],
        "orphaned_nodes": []
      }
    }
  },
  "summary": {
    "total_sources": 1,
    "passed": 1,
    "failed": 0,
    "overall_status": "PASSED"
  }
}